Fig. 8: Induction of cofilin-1 1-138 fragment in podocytes improved podocyte injury and renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN). | Cell Death & Disease

Fig. 8: Induction of cofilin-1 1-138 fragment in podocytes improved podocyte injury and renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN).

From: Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

Fig. 8

A Representative image showing Nephrin and WT1 immunostaining, podocyte foot process and glomerular basement membrane (GBM), and glomerular morphological changes in different groups of mice. White and black scale bar: 25 μm; red scale bar: 2 μm. B Quantification of WT1-positive cells. N = 5. C Quantitative analyses of the percentage of mesangial matrix area. N = 5. ****P < 0.0001, **P < 0.01, *P < 0.05, n.s. no significance, data were represented as mean ± SEM.

Back to article page