Fig. 7: STMN1 knockdown inhibits the cellular activities relative to HCC metastasis in vivo. | Cell Death & Disease

Fig. 7: STMN1 knockdown inhibits the cellular activities relative to HCC metastasis in vivo.

From: Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma

Fig. 7

A Orthotopic tumor formation was performed in the mice recipients with spleen transplantation of HCC97H-NC/STMN1-shRNA cells. Representative images of excised liver samples were shown on the left. H&E and STMN1 staining of orthotopic tumors were shown on the right. Scale bar: 100 um. B–D In vivo experimental metastatic assay was performed via spleen transplantation with MHCC97H-shCtl/shSTMN1 cells. H&E staining of metastatic tumor in the lung, the total number of metastatic foci, and large metastatic foci per mice were exhibited. Scale bar: 100 um. E A vivid model explaining how STMN1 affected the formation of MVI in early HCC via mediating microtubular stability and EMT.

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