Fig. 6: PCLAF knockdown restrained the growth of neuroblastoma in vivo.
From: PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis
(A) The volume of tumors obtained from xenografts was diminished in the PCLAF-knockdown group by shRNA from the SK-N-BE (2) cell line; (B, C) The volume and weight of tumors formed by PCLAF knockdown cells were dramatically smaller than that of the control; (D) The expression of PCLAF, PTTG1 and CyclinD1 were examined by western blot in tumors obtained from xenografts; (E) H&E staining of subcutaneous tumors in BALB/c nude mice; (F, G) Immunohistochemical staining of subcutaneous tumors on target of PCLAF, PTTG1 andCyclinD1 separately. (*p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001, and bar graphs represent the mean ± SEM).
