Fig. 5: JM2 induced apoptosis in the path of mitochondrion and cell cycle arrest. | Cell Death & Disease

Fig. 5: JM2 induced apoptosis in the path of mitochondrion and cell cycle arrest.

From: Juxtamembrane 2 mimic peptide competitively inhibits mitochondrial trafficking and activates ROS-mediated apoptosis pathway to exert anti-tumor effects

Fig. 5

a Mitochondrial membrane potential detection of B16F10 and 4T1 cells cultured with JM2 solutions with different concentrations. The change of aggregation/monomer ratio represent the change of mitochondrial membrane potential. b Apoptotic cells exhibited nuclear chromatin aggregation after being treated with JM2 solutions with different concentrations (white arrows). c Apoptotic effects and quantitative analysis of B16F10 and 4T1 cells cultured with JM2 solutions with different concentrations. d Cell cycle analysis of B16F10 and 4T1 cells cultured with JM2 solutions with different concentrations. *p < 0.05 and **p < 0.01 when the data was compared with the Control group.

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