Fig. 2: Omic changes of KYSE150 cells after oxethazaine treatment. | Cell Death & Disease

Fig. 2: Omic changes of KYSE150 cells after oxethazaine treatment.

From: Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A

Fig. 2

A General workflow of the proteomic and phospho-proteomic experimental strategy used to measure the peptide profiles of KYSE150 cells after 24 h of oxethazaine treatment (10 µM). B Volcano plot and statistic histogram shows that 498 sites changed significantly (p < 0.05) upon 24 h treatment with 10 µM oxethazaine. Blue and red dots represent down-regulated and up-regulated sites, respectively. C Heatmap illustrating differentially expressed proteins between DMSO and oxethazaine (10 µM) groups. D SwissTargetPrediction readout generated using the oxethazaine structure. E The number of protein predicted by phosphorylation sites (blue, left), the number of protein predicted by SwissTargetPrediction (yellow, right), and the intersection of these two (center).

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