Fig. 8: A proposed model of the ATP-HIF-1α signaling.
From: Extracellular ATP promotes breast cancer chemoresistance via HIF-1α signaling
Extracellular ATP could stimulate STAT3-ALDOA and AKT signaling via P2Y2 receptor and then regulate HIF-1α as well as HIF-1α target genes, among which ADM and PDK1 mediate ATP-driven chemoresistance.
