Fig. 1: Metformin suppressed the proliferation of CRC. | Cell Death & Disease

Fig. 1: Metformin suppressed the proliferation of CRC.

From: Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction

Fig. 1

a CCK8 assay detection of the cell viability of NCM460 cell and 7 CRC cells with or without 10 mM metformin treatment (Student’s t test). MTF metformin. b EdU assay evaluated the percentage of proliferative cells after treating 10 mM metformin for 24 h (Student’s t test). c Flow cytometry showing the effect of metformin on cell cycle distribution (Student’s t test). d, e The growth rate of the subcutaneous tumors (d) and the bodyweight of mice (e) with or without metformin treatment (two-way ANOVA). f The image, weight, and representative HE staining of subcutaneous tumors. Magnification: 50×. Scale bar: 200 µm. The values are shown as the mean ± SD and experiments were independently repeated three times. *P < 0.05, ***P < 0.001.

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