Fig. 8: Downregulation of the GZMA and F2R expressions predicted aggressive clinicopathological characteristics and poor prognosis in HCC patients. | Cell Death & Disease

Fig. 8: Downregulation of the GZMA and F2R expressions predicted aggressive clinicopathological characteristics and poor prognosis in HCC patients.

From: Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma

Fig. 8

A The mRNA levels of GZMA and F2R in 106 pairs of tumor tissues and adjacent tissues from HCC patients, analyzed using qRT-PCR. The relative GZMA and F2R expression were normalized using GAPDH(-ΔΔCT). B IHC staining was performed for GZMA and F2R in 158 pairs of tumor tissues and adjacent tissues from HCC patients. Scale bars: 2 mm for 50x and 50 μm for 400x. The average intensity of the gray color was used to indicate the relative levels of GZMA and F2R. *p < 0.05, *p < 0.01, ***p < 0.001, ****p < 0.0001. C The protein levels of GZMA and F2R in 42 pairs of tumor tissues and adjacent tissues from HCC patients were semi-quantified using the western blot assay. D The overall and tumor-free survival assays were performed for 106 low GZMA/F2R expression and high GZMA/F2R expression HCC patients. The patients at risk are listed below.

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