Fig. 5: Leptin influences LSCs through DHH signaling. | Cell Death & Disease

Fig. 5: Leptin influences LSCs through DHH signaling.

From: Leptin secreted from testicular microenvironment modulates hedgehog signaling to augment the endogenous function of Leydig cells

Fig. 5

Leptin augments LSCs through DHH signaling. Cells (LSCs, ALCs, Sertoli cells, PMCs) were treated with Vismodigib (DHH antagonist) in the presence of Leptin (1 or 10 ng/ml). Immunostaining showing expression of A alpha SMA, B SMHC, C Vimentin, and D B3HSD upon post-Vismodigib and leptin treatment. E Quantification of the experimental data to compare the effects of treatment. Asterisks denote p values (e.g., *p < 0.05, ****p < 0.001).

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