Fig. 7: Leptin-modulated molecular events, an enrichment analysis.

Enrichment analysis showing A Volcano plots showing significantly altered candidates upon increasing doses of leptin (0.25, 1, and 10 ng/ml) with respect to control. Green dots are those genes downregulated in the case sample and red dots are those upregulated in the case sample, with the top five genes in each direction being labeled. B The different cohorts represent the experimental observations UUD, UUN, DDU, and DDN, where U represents upregulated, D represents downregulated, and N represents no change. Each dot represents an individual gene within each designated pattern, with concentration plotted against fold change. C Heatmaps showing fold change with respect to the control for all patterns in genes across all concentrations. Heatmaps for UUN and DDN are split into two subplots showing the most differential fold change in the two major subgroups of fold change since fold change is not consistently the same across all genes.