Fig. 4: Expression profiles were analyzed according to protein and metabolic abundance between severe and non-severe COVID-19 survivors 6 months after discharge.

A–D The result of cluster analysis in processing conditions (Healthy-Non-severe-Severe) by the Mfuzz package. The result of continuous up-regulation proteins (A) and continuous down-regulation proteins (B). Results of continuously up-regulated metabolites (C) and continuously down-regulated metabolites (D). Numbers of proteins and metabolites are indicated for each cluster. Color bar represents Z score change from −1 to 1. E, F Barplot for function enrichment result (including KEGG and GO) for up-regulated proteins (E, protein cluster-up) and down-regulated proteins (F, protein cluster-down) (Top20); p value < 0.05 was identified as significantly changed terms. The X axis shows the p value of each term, and Y axis shows the function terms. G, H Heatmap visualization of up-regulated metabolites (G, metabolites cluster-up) and down-regulated metabolites (H, metabolites cluster-down) under the processing conditions (healthy, non-severe, severe).