Fig. 7: Fbxo45 promotes PC tumorigenesis. | Cell Death & Disease

Fig. 7: Fbxo45 promotes PC tumorigenesis.

From: Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation

Fig. 7

A Pictures of tumor masses dissected from Fbxo45-overexpressing xenograft mouse models. Panc-1 cells with stable Fbxo45 overexpression and the control cells were injected subcutaneously into the BALB/c-nu/nu mice to establish xenograft mouse models. B Tumor weights and tumor volumes of dissected tumor mass in (A). C IB analysis of the USP49 protein levels in the dissected tumors (left). USP49 protein abundance was quantified and plotted (right). D Pictures of tumor masses dissected from USP49-overexpressing xenograft mouse models. Panc-1 cells with stable USP49 overexpression and the control cells were injected subcutaneously into the BALB/c-nu/nu mice to establish xenograft mouse models. E Tumor weights and tumor volumes of dissected tumor mass in (D). F IB analysis of the USP49 protein levels in the dissected tumors. G Representative images of Fbxo45 and USP49 IHC staining from pancreatic cancer patients. H Survival curve for Fbxo45 in pancreatic cancer patients. I IHC scores of Fbxo45 in pancreatic cancer tissues and adjacent normal tissues. J Survival curve for USP49 in pancreatic cancer patients. K IHC scores of USP49 in pancreatic cancer tissues and adjacent normal tissues. L Statistical analyses of the correlation between Fbxo45 and USP49 expression in pancreatic cancer patients.

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