Fig. 2: CMTM6 suppresses HCC tumor growth in vitro and in vivo. | Cell Death & Disease

Fig. 2: CMTM6 suppresses HCC tumor growth in vitro and in vivo.

From: CMTM6 inhibits tumor growth and reverses chemoresistance by preventing ubiquitination of p21 in hepatocellular carcinoma

Fig. 2

A Western blot and B qPCR analysis results validated the regulation of CMTM6 in HuH-7 and HepG2. C CCK-8 assay and D colony-formation assay showing the cell growth of the indicated HCC cells. E Evaluation of the effects of CMTM6 on HCC cells proliferation by BrdU incorporation analysis. F Effects of CMTM6 on cell spontaneous apoptosis as assessed by flow cytometric analysis. G Images of the dissected tumors from the nude mice. H The tumor weight of each group is shown. I The tumor growth curves of each group are shown. All in vitro experiments were performed in triplicate. The error bars represent the mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns means non-significant.

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