Fig. 4: p21 was responsible for the CMTM6-mediated tumor suppression.

A Modulation of the CMTM6 and p21 expression in HCC cells was validated by Western blot analysis. B CCK-8 assays and (C) BrdU corporation assay showing the cell growth of the indicated HCC cells. D Cell cycle distribution of the indicated HCC cells as assessed by flow cytometric analysis. The experiments were performed in triplicate. The error bars represent the mean ± SD. *P < 0.05; ***P < 0.001; ****P < 0.0001.