Fig. 6: The therapeutic effects of BMSC-Exo on rat survival, renal function, cellular apoptosis and VC in 5/6 SNx rats. | Cell Death & Disease

Fig. 6: The therapeutic effects of BMSC-Exo on rat survival, renal function, cellular apoptosis and VC in 5/6 SNx rats.

From: Bone marrow mesenchymal stem cell-derived exosomal microRNA-381-3p alleviates vascular calcification in chronic kidney disease by targeting NFAT5

Fig. 6

A The pattern diagram of the research design in vivo. B Photograph of Sprague Dawley rats in the SHAM and SNx groups after treatment of BMSC-Exo. C, D Weight changes of rat in SHAM, SNx and SNx + Exo group were presented by histogram, *P < 0.05. E Concentrations of Scr and BUN in rats were presented by histogram. F, G Thoracic aorta of rats were stained by Alizarin Red S and V-K (upper panel scale bar = 200 μm, lower panel scale bar = 50 μm). (H) Ca2+ content and AKP activity were detected in SHAM, SNx, and SNx + Exo groups. I TUNEL staining was used to detect apoptosis in the thoracic aorta of rats (upper panel scale bar = 200 μm, lower panel scale bar = 50 μm). Positive staining, indicated with arrows, denotes the region of calcification or apoptosis in the thoracic aorta. *P < 0.05 compared with the SHAM group; #P < 0.05 compared with the SNx group.

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