Fig. 3: SLC25A38 is the upstream of several metastasis-related pathways.
From: SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma
A Pie chart illustrating differentially expression genes between SLC25A38-low tumors and SLC25A38-high tumors in TCGA UM RNA-seq dataset. B GSEA showing that SLC25A38 expression was negatively correlated with proliferative and metastatic gene signatures in the TCGA UM dataset. C Heatmap showing differentially expression genes in UM cells with SLC25A38 knock-out relative to control cells. D The most significant differentially GO items upon SLC25A38 knock-out. E Differentially expression genes in the SLC25A38-silenced UM cells in the indicated signaling pathways analyzed by qRT-PCR. F These series of networks demonstrated the changes in SLC25A38 and its neighboring genes (involving in cell proliferation, cell adhesion, cell motility, and angiogenesis) in terms of expression during metastasis in TCGA UM specimens and GSE22138 tumors.
