Fig. 4: Silencing SLC25A38 promotes the malignant properties of UM cells in vitro and in vivo.
From: SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma
A UM cells with SLC25A38 knock-out were successfully constructed. B, C Wound healing assay (B) and transwell invasion assay (C) showing that SLC25A38 knock-out could enhance the migration and invasion ability of UM cells. D Vascular ring formation analyses indicate the increasing ability of angiogenesis upon SLC25A38 knock-out. The number of tubes was counted and normalized tube length was calculated, scale bar 100 μm. E PET imaging and H&E staining showed that mice inoculated with SLC25A38 knock-out UM cells had more lung metastases and live metastases compared to that injected with control UM cells, scale bar 100 μm.
