Fig. 5: Downregulated SLC25A38 boosts angiogenesis.
From: SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma
A A proposed model underlying the role of SLC25A38 in UM angiogenesis. Through the promotion of the coactivator (CBP/p300) of HIF upon SLC25A38 knock-out, its target genes including pro-angiogenic factors are overexpressed and thus promote angiogenesis. GSEA of TCGA cohort and PCR validation of UM cells verified this proposal. B Correlation between SLC25A38 and CBP or CD31 protein expression in UM specimens. Tumor sections from 28 UM specimens were immunofluorescence stained with anti-SLC25A38, anti-CBP, and anti-CD31 antibodies. Left: representative images. Right: the correlation between SLC25A38 and CBP or CD31 protein expression was calculated by Pearson correlation coefficient. C Correlation between SLC25A38, CBP, FGF8, FGF12, TGFα, and CD31 expression in TCGA UM RNA-seq dataset. The Pearson correlation coefficient and P-value are indicated.
