Fig. 8: PRMT5 promotes TMAO-induced VCAM-1 expression via methylation of NF-κB p65 in VSMC.
From: PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells
H2O2 generated from the TMAO-stimulated Nox4 upregulation can promote PRMT5 expression and increase methylation of NF-κB p65 on R30, leading to the induction of VCAM-1 and macrophage adhesion.
