Fig. 5: BNIP3 silencing suppresses mitophagy.
From: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
Effect of 24 h of CDDP (25–50 µM) and of overnight of FCCP (10 µM) on mitophagy of 2008-C13 (A) and U2OS-U2OS-PT (C) transfected with non-targeting control (NTC, scramble) esiRNA or with an esiRNA targeting BNIP3 (esiBNIP3). The respective Mitophagy Index and quantification is reported in (B) and (D). Data are the mean ± SEM of 5–6 different experiments. *p < 0.05; calculated by a two-tailed unpaired t-test comparing esiRNA targeting BNIP3 (esiBNIP3) cells vs non-targeting control (NTC, scramble) esiRNA cells; *p < 0.05, ***p < 0.001, calculated by a two-tailed unpaired t-test comparing treated cells vs untreated cells.
