Fig. 1: Development of age-related cardiac dysfunction and sarcopenia in older rats. | Cell Death & Disease

Fig. 1: Development of age-related cardiac dysfunction and sarcopenia in older rats.

From: Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle

Fig. 1

A to D Echocardiographic assessment was performed in 4-, 18- and 24-month-old male F344 rats. A Representative pulse wave Doppler (PWD) measurements of mitral inflow (upper), tissue Doppler Imaging (TDI) of lateral wall motion at the septal annulus (middle), and left ventricular global longitudinal strain (GLS) curves (lower) were shown for the indicated age groups. B Left ventricular ejection fraction (LVEF) and left ventricular posterior wall at end-diastole (LVPWd) measured by M-mode echocardiography. C Global longitudinal and radial strain measured by strain echocardiography. D Ratios of the early (E) to late (A) diastolic mitral flow velocity, deceleration times (DT), isovolumic relaxation times (IVRT), and ratio of the early-diastolic mitral flow velocity (E) to early-diastolic mitral annular velocity (E’) evaluated for LV diastolic function. E Representative gastrocnemius (GA) muscles cross-section of the indicated age groups. DAPI, blue; WGA, red. Bar = 50 μm. F Frequency distributions of GA myofiber cross-sectional areas (CSA). J Mean CSA. H GA and tibialis anterior (TA) muscle weight relative to body weight (BW). I Quantification of the strength/stimulation frequency relationship in GA muscles. J Treadmill running time to exhaustion in rats of the indicated age groups. Data represent mean ± SD, n = 8 rats per group; The variance was similar among the groups. *P < 0.05, **P < 0.01.

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