Fig. 6: IPA analysis of potential RBMS1 regulatory mechanisms.
From: RBMS1 promotes gastric cancer metastasis through autocrine IL-6/JAK2/STAT3 signaling
A Heatmap showed the RBMS1-related differentially expressed genes using IPA software. B Top 20 affected disease functions based on IPA. The horizontal bars denote the different pathways based on the log (P value). Pink stars indicate the metastasis-related functions of cancer. C Hierarchical clustering of the DEGs (fold change = 2.0; FDR P < 0.05). Each column represents a sample, and each row represents a transcript. The expression level of each gene in a single sample is depicted according to the color scale. D, E The concentrations of cytokines in culture supernatants of HGC-27 and SGC-7901 cells were measured by Luminex assays after knockdown or overexpression of RBMS1. F–I The mRNA levels of cytokines were detected by qPCR in the RBMS1-KD and RBMS1-OE GC cell lines. NC negative control, OE overexpression, KD knockdown. NS not significant; *P < 0.05, **P < 0.01, ***P < 0.001.
