Fig. 6: T-ALL and B-ALL EVs affect HSPC maintenance in vitro. | Cell Death & Disease

Fig. 6: T-ALL and B-ALL EVs affect HSPC maintenance in vitro.

From: Acute lymphoblastic leukemia-derived extracellular vesicles affect quiescence of hematopoietic stem and progenitor cells

Fig. 6

Murine Lin− cells were treated ex vivo with EVs isolated from NSG control mice or ALL PDX models. A After 24 h, as assessed by flow cytometry on LSK gating cells, treatment with ALL EVs affects the numbers of HSC (SLAM). B This is further corroborated by an attrition of the primitive LSK CD34− cells. C Flow cytometry on LSK gating cells showing a loss of quiescent cells (in G0). On this figure, data are shown as means ± SD; n = 4 mice. P value are measured by one-way Anova with Tukey’s multiple comparison test; **P < 0.01; ***P < 0.001; ns, non-significant.

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