Fig. 3: Evaluation of the effect of CA-SBEβCD NPs administration on the learning and memory of APP/PS1 mice. | Cell Death & Disease

Fig. 3: Evaluation of the effect of CA-SBEβCD NPs administration on the learning and memory of APP/PS1 mice.

From: Inhibition of the CEBPβ-NFκB interaction by nanocarrier-packaged Carnosic acid ameliorates glia-mediated neuroinflammation and improves cognitive function in an Alzheimer’s disease model

Fig. 3

Four-month-old APP/PS1 (Tg) mice and age-matched C57BL/5 (WT) mice were orally gavaged with SBEβCD NPs (vehicle) or SBEβCD NPs loaded with 10 or 30 mg/kg CA for 5 months. A Representative images showing nests constructed by the mice. Nesting scores were quantified. B The recognition memory of WT and Tg mice was assessed by the NORT. The traces of the mice in the STM and LTM tests were recorded. The green dots and red dots respectively represent the starting and ending locations of the mice. Tg mice and WT mice showed similar total time and distance during the habituation phase. The discrimination index was used to compare the ability of the mice to recognise the familiar object. C Spatial learning and memory were evaluated by the MWM test. WT and Tg mice exhibited comparable escape latencies during the visible platform training phase. Tg mice performed longer escape latencies than WT mice in the hidden platform test from the 3rd day: CA treatment shortened the escape latency of Tg mice. D On the final day (the 8th day), the platform was removed, and the probe trial was performed. The number of times and the navigated distance of each mouse crossed the area in which the platform was previously located were quantified. E Representative traces show the exploration of the mice on the 7th and 8th day. *p < 0.05, ** p < 0.01, ***p < 0.001 vs vehicle-treated mice; #p < 0.05, ##p < 0.01 and ###p < 0.001 vs the WT mice by the repeated-measures ANOVA. Values represent the mean ± standard error of the mean (SEM). n = 8 in each group.

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