Fig. 7: Expression of CAD-regulated genes is associated with poor prognosis in cancer patients. | Cell Death & Disease

Fig. 7: Expression of CAD-regulated genes is associated with poor prognosis in cancer patients.

From: Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

Fig. 7

The prognostic impact of CAD deficient gene signatures on survival of patients from the TCGA data collection was examined using the CoxPH model. Association of a CAD-signature derived from Hela (A) and MDA-MB-231 (B) with survival. Signatures comprised of genes differentially expressed between control and CAD-deficient cells (padj < 0.01). Patients were assigned to high- vs. low-risk groups based on their expression levels of the signature genes in tumour vs. normal tissue. In all cases, a significant separation (log-rank p < 10−8) between high and low risk subjects is achieved. C, D Distant metastasis-free survival in a cohort of 958 breast cancer patients stratified according to the expression of the 10 most downregulated genes in each cell line.

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