Fig. 1: TIPE deficiency leads to increased tumorigenesis.
From: TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis
A Schematic of AOM/DSS protocol for induction of colorectal tumor. B Survival curve of WT (n = 15) and Tipe−/− (n = 15) mice undergoing AOM/DSS treatment. Data were pooled from three independent experiments. C Relative body weight change of WT (n = 5) and Tipe−/− (n = 5) mice during AOM/DSS protocol. Data are representative of three independent experiments. D, E Representative macroscopic images (D) and H&E-stained sections (E) of colon tumors from WT (n = 5) and Tipe−/− (n = 5) mice on day 90 of the CAC model. Scale bars, 100 μm; original magnification ×10. Data are representative of three independent experiments. F–H Colon tumor number (F), tumor load (G) and tumor-size distribution (H) of WT (n = 14) and Tipe−/− (n = 12) mice on day 90 after AOM/DSS treatment. Data were pooled from three independent experiments. Data are presented as mean ± SEM. Kaplan–Meier analysis (B) (p < 0.05) or Student’s t test (C, F, and G), *p < 0.05, **p < 0.01, ***p < 0.001.
