Fig. 3: TIPE deficiency accelerates inflammation-associated dysbiosis.
From: TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis
A Comparison of fecal specimens bacterial communities from WT (n = 5) and Tipe−/− (n = 5) mice on day 0 or day 14 of the CAC model at the top 3 phylum level by 16S rRNA sequencing. B PCoA analysis of microbiome in fecal specimens from WT (n = 5) and Tipe−/− (n = 5) mice on day 0 or day 14 of the CAC model by 16S rRNA sequencing. C Heatmap depicting of relative abundance of family level microbiota in the feces as in (B) (n = 3 per group). D Quantification analysis of Enterobacteriaceae family microbiota distribution in the feces as in (B) by 16S rRNA sequencing (n = 5 per group). E Quantitative PCR analysis of 16S rRNA genes of Proteobacteria phylum, Enterobacteriaceae family, E. coli and Lactobacillus species at colon mucosal surface of WT and Tipe−/− mice on day 0 or day 14 of the CAC model (n = 3 or 5 per group). Data are presented as mean ± SEM and are representative of three independent experiments. Student’s t test (D, E), *p < 0.05, **p < 0.01.
