Fig. 4: The intestinal microbiota is altered in tumor-bearing Tipe−/− mice.
From: TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis
A Operational taxonomic unit (OTU) abundances (left) and Shannon-Wiener diversity index (Shannon index) (right) of the feces from WT (n = 4) and Tipe−/− (n = 4) mice on day 90 of the CAC model by 16S rRNA sequencing. B PCoA analysis of microbiome in the feces from WT (n = 4) and Tipe−/− (n = 4) mice on day 90 of the CAC model by 16 S rRNA sequencing. C, D Relative abundance of microbiota at the top 15 phylum level (C), or the top 15 class level (D) in the feces by taxon-based analysis as in (A) (n = 4 per group). E Quantification analyses of Proteobacteria phylum, Gammaproteobacteria class and Enterobacteriaceae family microbiota distribution in the feces as in (A) (n = 4 per group). F Western blot analysis of p-H2A.X in WT (n = 3) and Tipe−/− (n = 3) colon tumors on day 90 of the CAC model. Blots represent data from the same biological samples run in parallel. Data are presented as mean ± SEM and are representative of three independent experiments. Student’s t test (A and E), *p < 0.05, **p < 0.01.
