Fig. 6: Restoration of hematopoietic TIPE fails to rescue Tipe−/− AOM/DSS phenotype.
From: TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis
Bone marrow transplants were performed on WT and Tipe−/− mice as indicated. A Schematic of experimental design. WT and Tipe−/− mice were irradiated, transferred with WT or Tipe−/− bone marrow cells, allowed to recover 8 weeks, and followed by AOM/DSS protocol. B, C Colon tumor number (B) and tumor load (C) of BM-transplanted WT and Tipe−/− as described in (A) (n = 5 per group). Data are representative of two independent experiments. Data are presented as mean ± SEM and are representative of two independent experiments. Student’s t test (B, C), **p < 0.01, ***p < 0.001.
