Fig. 2: Activating the HGF/c-Met signaling pathway promotes PNI in pancreatic cancer. | Cell Death & Disease

Fig. 2: Activating the HGF/c-Met signaling pathway promotes PNI in pancreatic cancer.

From: HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis

Fig. 2

A, B Cancer cell-DRG coculture model for the control and HGF groups in PANC-1 cells and BxPC-3 cells. C, D Western blot analysis of the expression of p-Met, c-Met, NGF at different HGF concentrations in PANC-1 cells and BxPC-3 cells. E, F Wound healing assay of the control and HGF groups in PANC-1 cells and BxPC-3 cells. G, H Transwell-based assay of the control and HGF groups in PANC-1 cells and BxPC-3 cells. I, J Western blot analysis of the expression of p-Met, c-Met, N-cadherin, E-cadherin, and Vimentin in PANC-1 cells and BxPC-3 cells treated with different HGF concentrations. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Back to article page