Fig. 1: KDM5B is upregulated in Ewing sarcoma and is associated with poor prognosis.
From: KDM5B promotes tumorigenesis of Ewing sarcoma via FBXW7/CCNE1 axis
A Box plot of KDM5B mRNA expression in GSE17674 between Ewing sarcoma samples and normal tissues. B KDM5B expression in Ewing sarcoma cell lines A673, SKNMC and RDES versus in normal cell line hMSC assessed by RT‐qPCR and C western blot analysis. D Representative immunohistochemistry images of KDM5B protein expression in Ewing sarcoma samples. Scale bars: 100 μm. E–G Kaplan-Meier analysis of correlation of KDM5B protein expression with overall survival (OS), event-free survival (EFS) and OS after progression in 46 Ewing sarcoma patients at our center. Error bars in B indicate standard deviation of three biological independent experiments. P values in A are determined by two‐tailed unpaired Student’s t test. P values in E, F, G are determined by log-rank test. *Above the bars indicates significant difference; ****P < 0.0001.
