Fig. 2: Features of eccDNAs detected in HGSOC samples. | Cell Death & Disease

Fig. 2: Features of eccDNAs detected in HGSOC samples.

From: Global characterization of extrachromosomal circular DNAs in advanced high grade serous ovarian cancer

Fig. 2

A The karyotype plots showing chromosomal distribution of eccDNA identified in each individual. Red, eccDNAs detected in metastatic tissues; Green, eccDNAs detected in primary tissues. B Size distributions of eccDNA in HGSOC (left panel) and HGSOC-M (right panel). Individuals were marked by different colors, respectively. Median was marked by white circles. C GC contents of eccDNA locus and regions immediately upstream and downstream from the eccDNA compared to the genomic average. HGSOC, upper panel; HGSOC-M, lower panel; Red, 1000 stretches upstream eccDNA locus (from eccDNA_start −1000 to eccDNA_start); Yellow, eccDNA (from eccDNA_start to eccDNA_end); Green, 1000 stretches downstream eccDNA locus (from eccDNA_end to eccDNA_end +1000); Black, 1000 random stretches of the genome of equivalent length as the eccDNA. D Genomic distributions of eccDNA in HGSOC-M (red) and HGSOC (green). Each dot represents an individual. CpG2kbD, 2 kb downstream of CpG islands; CpG2kbU, 2 kb upstream of CpG islands; Gene2kbD, 2 kb downstream of genes; Gene2kbU, 2 kb upstream of genes. E Repetitive regions from total mapped reads for eccDNAs derived from each sample. Red, HGSOC-M; Green, HGSOC. F EccDNA frequency relative to chromosome. EccDNA counts per Mb from HGSOC-M (red cross, n = 4) and HGSOC (green circle, n = 4) per chromosome.

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