Fig. 1: Hepatic BCL6 expression is decreased in genetic- and high-fat diet (HFD)-induced obese mice and NAFLD patients. | Cell Death & Disease

Fig. 1: Hepatic BCL6 expression is decreased in genetic- and high-fat diet (HFD)-induced obese mice and NAFLD patients.

From: B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36

Fig. 1

A Protein expression of BCL6 in livers of WT mice fed the NCD or HFD for 16 weeks (n = 4). B Hepatic mRNA expression of BCL6 of WT mice fed the NCD or HFD for 16 weeks (n = 6). mRNA expression of target genes was normalized to that of β-actin. C Protein expression of BCL6 in livers of lean mice and genetically obese mice (ob/ob mice) after 8 weeks of NCD (n = 4). D Hepatic mRNA expression of BCL6 of lean mice and ob/ob mice after 8 weeks of NCD (n = 4). E Protein expression of BCL6 in livers from normal subjects (n = 6) and NAFLD patients (n = 6). F Relative mRNA levels of BCL6 in livers from normal subjects (n = 6) and NAFLD patients (n = 6). G Representative images of H&E, Oil red O staining, hepatic BCL6 expression by immunohistochemistry of liver tissues from the 16-week-old NCD or HFD mice. Scale bar, 100 μm. H Representative immunohistochemistry staining of BCL6 in liver sections from normal subjects and NAFLD patients. Scale bar, 100 μm. I BCL6 protein expression in primary hepatocytes, which were isolated and stimulated with PA (0.3 mM) for 24 h. The data represent mean ± SD. J mRNA level of BCL6 in primary hepatocytes, which were isolated and stimulated with PA (0.3 mM) for 24 h. mRNA expression of target genes was normalized to that of β-actin. Data represent the mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001 and N.S. indicates no significance between the two indicated groups.

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