Fig. 3: Loss-of-function of STEAP2 inhibits the proliferation and migration of PTC cells. | Cell Death & Disease

Fig. 3: Loss-of-function of STEAP2 inhibits the proliferation and migration of PTC cells.

From: METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition

Fig. 3

A-B The knockdown effect on STEAP2 was detected by RT-qPCR and western blot after transfection of K1 and KTC-1 cells with designed siRNAs targeting STEAP2 (si-STEAP2) or negative control (si-NC). C–E CCK-8 assay, colony formation assay, and EdU assay were used to determine the viability of BCPAP and TPC-1 cells after STEAP2 silencing. Scale bar: 50 μm. F–H Wound healing assay, transwell migration assay, and transwell invasion assay were performed to evaluate the migration ability of K1 and KTC-1 cells after STEAP2 activation. All data are presented as the mean ± standard deviation of three independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001.

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