Fig. 5: miR-532 inhibits GC cell proliferation, G1/S transition and promotes apoptosis and DNA damage by suppressing E2F1 in vitro. | Cell Death & Disease

Fig. 5: miR-532 inhibits GC cell proliferation, G1/S transition and promotes apoptosis and DNA damage by suppressing E2F1 in vitro.

From: The miR-532-E2F1 feedback loop contributes to gastric cancer progression

Fig. 5

A, B Cell proliferation assays (CCK8 and EdU) were performed in MKN-45 cells transfected with miR-532 mimics, E2F1 vector or E2F1 vector plus miR-532 mimics. A: CCK-8 assay; B: EdU assay. C, D Histogram statistics from cell cycle and apoptosis assays. E–H Analysis of cell proliferation, cycle and apoptosis in MKN-45 cells transfected with miR-532 inhibitors, si-E2F1 or si-E2F1 plus miR-532 inhibitors. *P < 0.05; **P < 0.01; ***P < 0.001.

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