Fig. 3: Downregulation of insulin receptor signaling in the rd10 mouse retina.
From: Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa
A Representative images of the OPL of P23 retinal sections from WT and rd10 mice co-immunostained for pS6Ser240/244 (green) and calbindin (red). Asterisks indicate horizontal cell bodies. Insets show amplification (2.5X) of the indicated area. Scale bar: 6 μm. B Quantification of the number of horizontal terminal tips (calbindin+ puncta) with apposite pS6Ser240/244 labeling. Data are presented as the mean + SEM. n = 4 mice, 4 images. Over 200 calbindin+ tips were scored per retina. ***p ≤ 0.001 versus WT (unpaired T-test).
