Fig. 5: AAV-hPi treatment results in sustained human proinsulin production.
From: Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa
A rd10 mice received a single intramuscular injection of AAV-hPi or AAV-null at P10 and were analyzed at different timepoints post-injection. B Long-term monitoring of serum human proinsulin levels as determined by ELISA in individual rd10 mice injected with AAV-hPi. Human proinsulin levels in AAV-null mice were under the detection threshold of the assay (0.5 pM). C, D Long-term monitoring of glucose levels (C) and body weight (D) in AAV-hPi or AAV-null injected rd10 mice. Data are presented as the mean + SEM. n = 4 mice in B and 4–6 mice per group in C and D.
