Fig. 8: Effect of AAV-hPi administration on optokinetic response.
From: Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa
rd10 mice received a single intramuscular injection of AAV-null or AAV-hPi at P10. The optomotor test was performed at the indicated ages. A, B Schematic depicting the optomotor test (A); 5 different spatial frequencies were tested (0.022–0.355 cycles/degree) and the contrast of the moving bars was adjusted (from 100% to 5%) to determine contrast sensitivity (B). C, D Optokinetic responses recorded at the indicated ages in AAV-null- and AAV-hPi treated rd10 mice. Contrast sensitivity is represented as a function of spatial frequency. Data are presented as the mean + SEM. n = 6 mice. P40 (****p ≤ 0.0001) and P50 (*p ≤ 0.05) (2-way ANOVA).
