Fig. 6: Ageing related hypothyroidism promotes exosomal transport of liver-derived ApoE4 to the brain, thus activating NLRP3 inflammasome and cause neurological impairments. | Cell Death & Disease

Fig. 6: Ageing related hypothyroidism promotes exosomal transport of liver-derived ApoE4 to the brain, thus activating NLRP3 inflammasome and cause neurological impairments.

From: Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment

Fig. 6

Ageing-associated hypothyroidism promotes liver-derived ApoE4 exosomal transport. ApoE4-laden exosomes exosomes to cross BBB entering the brain A, liver-derived ApoE4-reach exosomes also enter CSF in choroid plexus B. Both processes result in the accumulation of ApoE4 in the brain. Elevated ApoE4 increases the cholesterol level in neural cells, which suppresses mitochondrial content of GSH and UCP4 thus leading to an increase in ROS. Increased ROS activates NLRP3 inflammasome triggering pyroptosis, that contributes to neurocognitive decline and depression.

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