Fig. 1: SHANK1 is upregulated in NSCLC samples and causes cell proliferation in NSCLC cell lines. | Cell Death & Disease

Fig. 1: SHANK1 is upregulated in NSCLC samples and causes cell proliferation in NSCLC cell lines.

From: SHANK1 facilitates non-small cell lung cancer processes through modulating the ubiquitination of Klotho by interacting with MDM2

Fig. 1

A SHANK1 expression was examined by immunohistochemical staining of NSCLC tissue samples. B Protein expression of SHANK1, SHANK2 and SHANK3 in NSCLC samples, as measured by WB, relative to that of Tubulin. T tumor. N normal. C Prognostic value of SHANK1 in NSCLC patients were assessed by using the Kaplan–Meier (KM) plotter integrative data analysis tool (http://www.kmplot.com). The desired Affymetrix ID is valid: 220563_at (SHANK1). Survival curves are plotted for all NSCLC patients (ALL). Survival curves are plotted for adenocarcinoma patients (LUAD). Survival curves are plotted for squamous cell carcinoma patients (LUSC). D, E Survival curves are plotted for non-smoker, smoker, and male patients. F, G Protein expression of SHANK1, SHANK2 and SHANK3 in different lung cancer cell lines.

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