Fig. 7: SHANK1 knocking-down decrease NSCLC tumorigenesis in vivo. | Cell Death & Disease

Fig. 7: SHANK1 knocking-down decrease NSCLC tumorigenesis in vivo.

From: SHANK1 facilitates non-small cell lung cancer processes through modulating the ubiquitination of Klotho by interacting with MDM2

Fig. 7

A, B The nude mice were inoculated with either A549 cells stably expressing shNC or sh-SHANK1, and the xenograft tumors were photographed. C Tumor weight at the end point (3 weeks). **p < 0.01, compared with NC group student’s t test. D The expression of KL, Shank1, Bcl-2 and c-Myc of tumor xenograft was examined by immunoblotting. E Simplified model depicting the complex of KL, MDM2, and SHANK1.

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