Fig. 9: Mutant FOXC1 increases KLF10 through epigenetic modification. | Cell Death & Disease

Fig. 9: Mutant FOXC1 increases KLF10 through epigenetic modification.

From: Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia

Fig. 9

a Dual-luciferase reporter system detecting the transcription activation of FOXC1 on HDAC1. b H3K27ac distribution in the promoter region of KLF10. c Enrichment of H3K27Ac in the promoter region of KLF10 in patients with ALL. d Enrichment of H3K27Ac, detected through multisite ChIP-PCR around KLF10 loci in cells treated with FOXC1 with different types, as normalized to the input. All experiments were performed in triplicate. Data are presented as means ± SEM. (*p < 0.05).

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