Fig. 1: CircLIFR is downregulated in HCC and correlates with poor prognosis. | Cell Death & Disease

Fig. 1: CircLIFR is downregulated in HCC and correlates with poor prognosis.

From: CircLIFR suppresses hepatocellular carcinoma progression by sponging miR-624-5p and inactivating the GSK-3β/β-catenin signaling pathway

Fig. 1

A Heatmap of the differentially expressed circular RNAs in five HCC and adjacent non-tumor tissues. The red scales denote higher expression levels, while the purple scales represent lower expression levels. B qRT-PCR analysis to confirm the resistance of circLIFR and linear LIFR, with and without RNase R treatment, in Huh7 and SUN387 cells. C Actinomycin D treatment to assess the stability of circLIFR and LIFR mRNA over time in Huh7 and SUN387 cells. D Results of qRT-PCR to detect the expression of circLIFR in 60 pairs of tumor and adjacent tissues from HCC patients. E, F Kaplan–Meier analysis showing the correlation of circLIFR expression and overall survival or recurrence-free survival in HCC patients. Data represent means ± SD of three independent experiments. *P < 0.05.

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