Fig. 5: CircLIFR inhibits HCC cell proliferation, migration, and invasion via sponging miR-624-5p. | Cell Death & Disease

Fig. 5: CircLIFR inhibits HCC cell proliferation, migration, and invasion via sponging miR-624-5p.

From: CircLIFR suppresses hepatocellular carcinoma progression by sponging miR-624-5p and inactivating the GSK-3β/β-catenin signaling pathway

Fig. 5

A Colony formation assays show that transfection with miR-624-5p mimics promotes the proliferation ability of Huh7 cells and reverses the proliferation inhibition induced by overexpression of circLIFR in Huh7 cells. B Colony formation assays demonstrate that miR-624-5p inhibitor suppresses the proliferation ability of SNU387 cells and restores the proliferation promotion effect induced by downregulation of circLIFR in SNU387 cells. C–E Transwell assays show the effect of miR-624-5p mimics, circLIFR, or combination of both on the migration and invasion ability of Huh7 cells. D–F Transwell assays showing the effect of miR-624-5p inhibitor, circLIFR-shRNA, or combination of both on the migration and invasion ability of SNU387 cells. Scale bar: 100 μm. Data represent means ± SD of three independent experiments. *P < 0.05.

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