Fig. 6: circLIFR regulates GSK-3β/β-catenin signaling pathway via sponging miR-624-5p. | Cell Death & Disease

Fig. 6: circLIFR regulates GSK-3β/β-catenin signaling pathway via sponging miR-624-5p.

From: CircLIFR suppresses hepatocellular carcinoma progression by sponging miR-624-5p and inactivating the GSK-3β/β-catenin signaling pathway

Fig. 6

A Schematic illustration showing the potential target genes of miR-624-5p as predicted by TarBase, Starbase, and TargetScan. B The matched sequence of miR-624-5p with the 3′UTR of Glycogen synthase kinase 3β (GSK-3β) and luciferase reporter assays verify the relationship between miR-624-5p and GSK-3β. C, D Rescue assays demonstrate that circLIFR can modulate the expression of GSK-3β via miR-624-5p. E, F Western blot analysis for β-catenin protein levels in protein lysates, isolated at the indicated time points from HCC cells treated with 10 μM cycloheximide. Data represent means ± SD of three independent experiments. *P < 0.05.

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