Fig. 4: Adoptive transfer of Tim-3+Mφs relieved murine embryo absorption induced by Mφ depletion. | Cell Death & Disease

Fig. 4: Adoptive transfer of Tim-3+Mφs relieved murine embryo absorption induced by Mφ depletion.

From: Tim-3+ decidual Mφs induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132

Fig. 4

A Representative images of uterus and the percent of fetal resorption in pregnant CBA/J mice with Mφ depletion or those that received adoptive transfer of Tim-3+Mφs or Tim-3−Mφs and at GD 4.5. Data represent the mean ± SEM of n = 4 mice per group and are representative of three independent analyses. ***p < 0.001, compared with the control group. ##p < 0.01, compared with the group of Tim-3+Mφs. B Flow cytometric analysis and quantification of frequency of surface molecule, cytokine and transcription factor expression by dF4/80+ cells from pregnant CBA/J females with Mφ depletion after adoptive transfer of Tim-3+Mφs or Tim-3−Mφs. Data represent the mean ± SEM of n = 6–9 mice per group. *p < 0.05, **p < 0.01, compared with the Tim-3+Mφs group. C Quantification of flow cytometric analysis of cytokine production and transcription factor expression by dCD4+ T cells from pregnant CBA/J females with Mφ depletion or those that received adoptive transfer of Tim-3+Mφs or Tim-3−Mφs. Data represent the mean ± SEM of n = 3–6 mice per group. *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control group. #p < 0.5, ##p < 0.01, ###p < 0.001, compared with the group of Tim-3+Mφs.

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