Fig. 7: TMP269 attenuates WNT5A-mediated ESCC cell migration and invasion. | Cell Death & Disease

Fig. 7: TMP269 attenuates WNT5A-mediated ESCC cell migration and invasion.

From: WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway

Fig. 7

A Representative western blots showing the levels of FLAG-WNT5A, HDAC7, SNAIL, E-cadherin, and vimentin in WNT5A-overexpressing EC109 and KYSE450 cells after treatment with TMP269 for 48 h. β-actin was used as an internal control. B, C Representative images and statistical analysis of wound healing assays and Transwell migration/invasion assays using WNT5A-overexpressing ESCC cells after treatment with TMP269 (20 μM) for 48 h. The migratory ability in wound healing assays was expressed as the mean scratch area. The initial scratch area (0 h) was set to 100%. *P < 0.05 compared with the LV-Control group, #P < 0.05 compared with the LV-Control + TMP269 group, and &P < 0.05 compared with the LV-WNT5A group. LV lentivirus. D Schematic diagram of the mechanism by which WNT5A promotes tumor metastasis by activating the HDAC7/SNAIL signaling pathway in ESCC.

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