Fig. 4: Ferroptosis regulates SIO-induced RPE degeneration in vivo.
From: Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
A H&E-stained retinal sections from mice receiving vehicle, SIO, and/or Fer-1 administration. Scale bar = 200 µm. B A schematic diagram showing the location of areas on retinal sections used for total retinal thickness and outer segment thickness measurement. C Quantitative analysis of total retinal thickness (central). n = 6 (biological replicates). D Quantitative analysis of total retinal thickness (middle). n = 6 biological replicates. E Quantitative analysis of total retinal thickness (peripheral). n = 6 (biological replicates). F Quantitative analysis of outer photoreceptor thickness (central). n = 6 (biological replicates). G Quantitative analysis of photoreceptor outer segment (OS) thickness (middle). n = 6 (biological replicates). H Quantitative analysis of photoreceptor outer segment (OS) (peripheral). n = 6 (biological replicates). I Labile iron level in RPE after SIO challenge with/without Fer-1 pre-treatment. n = 6 (biological replicates). J Total GSH level of RPE in SIO-induced RPE degeneration with/without Fer-1 pre-treatment. n = 6 (biological replicates). K MDA level of RPE in SIO-induced RPE degeneration with/without Fer-1 pre-treatment. n = 6 (biological replicates). *p < 0.05, **p < 0.01, ***p < 0.001.
