Fig. 7: FSP1-CoQ10-NADH pathway is involved in SIO-induced retinal pathology resembling age-related macular degeneration in vivo.
From: Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
A 4-HNE/FSP1 immunofluorescence in retinal sections of mice receiving vehicle, SIO and/or Fer-1 injections. Scale bar = 200 µm. B Quantitative analysis of fluorescent intensity of FSP1. n = 6 (biological replicates). C Quantitative analysis of fluorescent intensity of 4-HNE. n = 6 biological replicates. D NADH level of SIO-induced retinal pathology resembling age-related macular degeneration with/without Fer-1 treatment. n = 6 (biological replicates). E NAD+/NADH ratio of SIO-induced retinal pathology resembling age-related macular degeneration with/without Fer-1 treatment. n = 6 (biological replicates). F CoQ10 level of SIO-induced retinal pathology resembling age-related macular degeneration with/without Fer-1 treatment. n = 6 (biological replicates). *p < 0.05, **p < 0.01, ***p < 0.001.
