Table 1 Hepatic gene expression of (A) anti-apoptotic proteins and (B) NF-κB subunits in Bcl-3Hep and WT mice at 4 h post d-GalN/LPS challenge and in control animals.

From: Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure

(A)

 

WT + PBS

WT + d-GalN/LPS

Bcl-3Hep + PBS

Bcl-3Hep + d-GalN/LPS

BCL-2

1.00 ± 0.21

41.46 ± 8.58 ($)

0.88 ± 0.08

23.39 ± 1.72 ($$)

BCL-XL

1.00 ± 0.12

0.59 ± 0.03 ($)

0.57 ± 0.02

0.95 ± 0.43

cIAP1

1.00 ± 0.11

4.10 ± 0.48 ($)

0.83 ± 0.10

3.00 ± 0.35 ($$)

c-FLIPL

1.00 ± 0.07

0.89 ± 0.05

0.92 ± 0.04

0.81 ± 0.03

c-FLIPS

1.00 ± 0.06

0.96 ± 0.06

0.78 ± 0.05

1.06 ± 0.06

MCL-1

1.00 ± 0.04

0.60 ± 0.08

1.17 ± 0.24

0.66 ± 0.12

A20

1.00 ± 0.06

5.41 ± 0.80 ($)

0.76 ± 0.06

4.29 ± 0.10 ($)

XIAP

1.00 ± 0.04

0.81 ± 0.03 ($)

0.95 ± 0.1

0.74 ± 0.06

(B)

p50/p105

1.00 ± 0.09

2.44 ± 0.25 ($)

0.83 ± 0.05

1.90 ± 0.1 ($$)

c-Rel (Rel)

1.00 ± 0.17

1.03 ± 0.13

0.77 ± 0.06

1.70 ± 0.55 ($)

p65 (RelA)

1.00 ± 0.25

0.39 ± 0.13

0.19 ± 0.02 (*)

0.53 ± 0.08 ($)

RelB

1.00 ± 0.08

2.84 ± 0.53 ($)

0.99 ± 0.13

2.62 ± 0.02 ($)

  1. Data in (A) and (B) are shown as mean of n = 3-6 mice/group ± SEM. *p < 0.05 for WT vs. Bcl-3Hep and $p < 0.05, $$p < 0.01 for PBS vs. d-GalN/LPS using Mann–Whitney U test (A and B). There was no statistically significant difference between WT + d-GalN/LPS vs. Bcl-3Hep + d-GalN/LPS in respect of the parameters.
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